East Tennessee State University (ETSU) is a public research university in Johnson City, Tennessee. It was historically part of the State University and Community College System of Tennessee under the Tennessee Board of Regents, but since 2016, the university has been transitioning to governance by a separate institutional Board of Trustees. As of May 2017, it is the fourth largest university in the state and has off-campus centers in nearby Kingsport, Elizabethton, and Sevierville.

Johnson City is a city in Washington, Carter, and Sullivan counties in the U.S. state of Tennessee, mostly in Washington County. As of the 2020 United States census, the population was 71,046, making it the eighth largest city in Tennessee. Johnson City is the principal city of the Johnson City Metropolitan Statistical Area, which consists of Carter, Unicoi, and Washington counties and had a population of 207,285 as of 2020. The MSA is also a component of the Tri-Cities region. This CSA is the fifth-largest in Tennessee, with a population of 514,899 as of 2020.