Edward Jenner was an English physician and scientist who pioneered the concept of vaccines and created the smallpox vaccine, the world's first vaccine. The terms vaccine and vaccination are derived from Variolae vaccinae, the term devised by Jenner to denote cowpox. He used it in 1798 in the title of his Inquiry into the Variolae vaccinae known as the Cow Pox, in which he described the protective effect of cowpox against smallpox.

Berkeley is a market town and civil parish in the Stroud District in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway. The town is noted for Berkeley Castle, where the imprisoned King Edward II is believed to have been murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish includes the village of Berkeley Heath.