Edward Plantagenet, 17th Earl of Warwick was the son of Isabel Neville and George Plantagenet, 1st Duke of Clarence, and a potential claimant to the English throne during the reigns of both his uncle, Richard III (1483–1485), and Richard's successor, Henry VII (1485–1509). He was also a younger brother of Margaret Pole, 8th Countess of Salisbury. Edward was tried and executed for treason in 1499.

Lady Isabel Neville was the elder daughter and co-heiress of Richard Neville, 16th Earl of Warwick, and Anne de Beauchamp, suo jure 16th Countess of Warwick. She was the wife of George Plantagenet, 1st Duke of Clarence. She was also the elder sister of Anne Neville, wife and consort of Clarence's brother, Richard III.