Expedition 59 was the 59th Expedition to the International Space Station. It started with the arrival of the Soyuz MS-12 spacecraft carrying Aleksey Ovchinin, Nick Hague and Christina Koch, joining Oleg Kononenko, David Saint-Jacques and Anne McClain who transferred from Expedition 58. The expedition formally began on March 15, 2019. Ovchinin and Hague were originally meant to fly to the ISS aboard Soyuz MS-10, but returned to Earth minutes after takeoff due to a contingency abort. The expedition formally ended with the undocking of the Soyuz MS-11 spacecraft carrying Kononenko, Saint-Jacques and McClain on 24 June 2019; Ovchinin, Hague and Koch transferred to Expedition 60.

Soyuz MS-12 was a Soyuz spaceflight which launched on 14 March 2019, carrying three members of the Expedition 59 crew to the International Space Station. The mission ended on 3 October 2019, when Soyuz-MS-12 successfully landed.