Fayette County is a county located in the U.S. state of Tennessee. As of the 2020 census, the population was 41,990. Its county seat is Somerville. The county was named after the Marquis de la Fayette, French hero of the American Revolution. A part of the Memphis, TN-MS-AR Metropolitan Statistical Area, Fayette County is culturally alike to the Mississippi Delta and was a major area of cotton plantations dependent on slave labor in the nineteenth century.

The Memphis–Clarksdale-Forrest City Combined Statistical Area, TN–MS–AR (CSA) is the commercial and cultural hub of the Mid-South or Ark-Miss-Tenn. The census-defined combined statistical area covers eleven counties in three states, Tennessee, Mississippi, and Arkansas. As of 2020 census, the Memphis metropolitan area had a population of 1,389,905 The Forrest City, Arkansas Micropolitan area was added to the Memphis area in 2012 to form the Memphis–Forrest City Combined Statistical area. In 2023 the Clarksdale, Mississippi Micropolitan area was also added to form the new Memphis-Clarksdale-Forrest City Combined Statistical Area which as of 2023 had a population of roughly 1.4 million people according to census estimates.