In creation myths, the term "Five Suns" refers to the belief of certain Nahua cultures and Aztec peoples that the world has gone through five distinct cycles of creation and destruction, with the current era being the fifth. It is primarily derived from a combination of myths, cosmologies, and eschatological beliefs that were originally held by pre-Columbian peoples in the Mesoamerican region, including central Mexico, and it is part of a larger mythology of Fifth World or Fifth Sun beliefs.

Human sacrifice was common in many parts of Mesoamerica, so the rite was nothing new to the Aztecs when they arrived at the Valley of Mexico, nor was it something unique to pre-Columbian Mexico. Other Mesoamerican cultures, such as the Purépechas and Toltecs, and the Maya performed sacrifices as well and from archaeological evidence, it probably existed since the time of the Olmecs, and perhaps even throughout the early farming cultures of the region. However, the extent of human sacrifice is unknown among several Mesoamerican civilizations. What distinguished Aztec practice from Maya human sacrifice was the way in which it was embedded in everyday life. These cultures also notably sacrificed elements of their own population to the gods.