Florence is a city in and the county seat of Florence County, South Carolina, United States. It lies at the intersection of Interstates 20 and 95 and is the eastern terminus of the former. It is the primary city within the Florence metropolitan area. The area forms the core of the historical Pee Dee region of South Carolina, which includes the eight counties of northeastern South Carolina, along with sections of southeastern North Carolina. As of the 2020 census, the population of the city was 39,899, making it the 10th-most populous city in the state.

Florence County is a county located in the U.S. state of South Carolina. As of the 2020 census, its population was 137,059. Its county seat is Florence.