Francesco Maria I della Rovere was an Italian condottiero, who was Duke of Urbino from 1508 to 1516 and, after retaking the throne from Lorenzo II de' Medici, from 1521 to 1538.

The House of Della Rovere was a powerful Italian noble family. It had humble origins in Savona, in Liguria, and acquired power and influence through nepotism and ambitious marriages arranged by two Della Rovere popes: Francesco Della Rovere, who ruled as Sixtus IV from 1471 to 1484 and his nephew Giuliano, who became Julius II in 1503. Sixtus IV built the Sistine Chapel, which was named after him. Julius II was patron to Michelangelo, Raphael and many other Renaissance artists and started the modern rebuilt of St. Peter's Basilica. Also the Basilica of San Pietro in Vincoli in Rome was the family church of the Della Rovere. Members of the family were influential in the Church of Rome, and as dukes of Urbino, dukes of Sora and lords of Senigallia; the title of Urbino was extinguished with the death of Francesco Maria II in 1631, and the family died out with the death of his granddaughter Vittoria, Grand Duchess of Tuscany.