Francis Nash was a brigadier general in the Continental Army during the American Revolutionary War. Prior to the war, he was a lawyer, public official, and politician in Hillsborough, North Carolina, and was heavily involved in opposing the Regulator movement, an uprising of settlers in the North Carolina piedmont between 1765 and 1771. Nash was also involved in North Carolina politics, representing Hillsborough on several occasions in the colonial North Carolina General Assembly.

The 1st North Carolina Regiment of the Continental Army was raised on September 1, 1775, at Wilmington, North Carolina. In January 1776 the organization contained eight companies. Francis Nash was appointed colonel in April 1776. The regiment was present at the defense of Charleston in 1776. It transferred from the Southern Department to George Washington's main army in February 1777. At that time, Thomas Clark became colonel of the 1st Regiment. The regiment became part of General Francis Nash's North Carolina Brigade in July.