Lieutenant-General Francis Nicholson was a British Army general and colonial official who served as the governor of South Carolina from 1721 to 1725. He previously was the Governor of Nova Scotia from 1712 to 1715, the Governor of Virginia from 1698 to 1705, the Governor of Maryland from 1694 to 1698, the Lieutenant Governor of Virginia from 1690 to 1692, and the Lieutenant Governor of the Dominion of New England from 1688 to 1689.

The Dominion of New England in America (1686–1689) was an administrative union of English colonies covering all of New England and the Mid-Atlantic Colonies, with the exception of the Delaware Colony and the Province of Pennsylvania. The region's political structure was one of centralized control similar to the model used by the Spanish monarchy under the Viceroyalty of New Spain. The dominion was unacceptable to most colonists because they deeply resented being stripped of their rights and having their colonial charters revoked. Governor Edmund Andros tried to make legal and structural changes, but most of these were undone and the Dominion was overthrown as soon as word was received that King James II had vacated the throne in England. One notable change was the forced introduction of the Church of England into Massachusetts, whose Puritan leaders had previously refused to allow it any foothold.