Frosinone is a comune (municipality) in the Italian region of Lazio, administrative seat of the province of Frosinone. It is about 75 kilometres (47 mi) southeast of Rome, close to the Rome-Naples A1 Motorway. The city is the main city of the Valle Latina, an Italian geographical and historical region that extends from south of Rome to Cassino.

Lazio or Latium is one of the 20 administrative regions of Italy. Situated in the central peninsular section of the country, it has 5,714,882 inhabitants and a GDP of more than €197 billion per year, making it the country's second most populated region and second largest regional economy after Lombardy. The capital of Lazio is Rome, which is also the capital and largest city of Italy, and completely encircles a foreign nation.