The Garamantes were ancient peoples, who may have descended from Berber tribes, Toubou tribes, and Saharan pastoralists that settled in the Fezzan region by at least 1000 BC and established a civilization that flourished until its end in the late 7th century AD. The Garamantes first emerged as a major regional power in the mid-2nd century AD and established a kingdom that spanned roughly 180,000 km2 (70,000 sq mi) in the Fezzan region of southern Libya. Their growth and expansion was based on a complex and extensive qanat irrigation system, which supported a strong agricultural economy and a large population. They subsequently developed the first urban society in a major desert that was not centered on a river system; their largest town, Garama, had a population of around four thousand, with an additional six thousand living in surrounding suburban areas. At its pinnacle, the Garamantian kingdom established and maintained a "standard of living far superior to that of any other ancient Saharan society" and was composed of "brilliant farmers, resourceful engineers, and enterprising merchants who produced a remarkable civilization."

Berbers or the Berber peoples, also called by their endonym Amazigh or Imazighen, are a diverse grouping of distinct ethnic groups indigenous to North Africa who predate the arrival of Arabs in the Arab migrations to the Maghreb. Their main connections are identified by their usage of Berber languages, most of them mutually unintelligible, which are part of the Afroasiatic language family. They are indigenous to the Maghreb region of North Africa, where they live in scattered communities across parts of Morocco, Algeria, Libya, and to a lesser extent Tunisia, Mauritania, northern Mali and northern Niger. Smaller Berber communities are also found in Burkina Faso and Egypt's Siwa Oasis.