Genova Piazza Principe railway station is the central station of Genoa and is located on Piazza Acquaverde, occupying the entire north side of Via Andrea Doria—where the station entrance is located—in the town centre and a short distance from the Palazzo del Principe, from which it takes its name. It is used by about 66,000 passengers per day and 24,000,000 per year. The first temporary station was opened in 1854 at the end of the line from Turin. Lines were later opened to Milan, Rome and the French border at Ventimiglia.

The Turin–Genoa railway line is a major Italian rail line, connecting the cities of Turin and Genoa. It is 169 kilometres (105 mi) long.