Greenville–Spartanburg International Airport is near Greer, South Carolina, United States, midway between Greenville and Spartanburg, the major cities of the Upstate region. The airport is the third-busiest airport in South Carolina, after Charleston International Airport, and Myrtle Beach International Airport with over 2.56 million passengers in 2023.

Greer is a city in Greenville and Spartanburg counties in the U.S. state of South Carolina. The population was 35,308 as of the 2020 census, making it the 14th-most populous city in South Carolina. Greer is included in the Greenville-Anderson-Greer, SC Metropolitan Statistical Area, which is part of the Greenville-Spartanburg-Anderson, SC Combined Statistical Area in Upstate South Carolina.