Greenwood County is a county located in the U.S. state of South Carolina. As of the 2020 census, its population was 69,351. Its county seat is Greenwood.

Greenwood is a city in and the county seat of Greenwood County, South Carolina. The population in the 2020 United States Census was 22,545 down from 23,222 at the 2010 census. The city is home to Lander University.