Hampden–Sydney College (H-SC) is a private liberal arts men's college in Hampden Sydney, Virginia. Founded in 1775, Hampden–Sydney is the oldest privately chartered college in the Southern United States, the tenth-oldest college in the US, the last college founded before the American Declaration of Independence, and the oldest of only three four-year, all-male liberal arts colleges remaining in the United States. Hampden–Sydney College is listed on the National Register of Historic Places and the Virginia Landmarks Register. It is affiliated with the Presbyterian Church (USA).

Liberal arts colleges in the United States are undergraduate institutions of higher education in the United States that focus on a liberal arts education. The Encyclopædia Britannica Concise defines liberal arts as a "college or university curriculum aimed at imparting general knowledge and developing general intellectual capacities, in contrast to a professional, vocational, or technical curriculum". Generally, a full-time, four-year course of study at a liberal arts college leads students to earning the Bachelor of Arts or the Bachelor of Science.