Helena is the eastern portion of Helena–West Helena, Arkansas, a city in Phillips County, Arkansas, located on the west bank of the Mississippi River. It was founded in 1833 by Nicholas Rightor and is named after the daughter of Sylvanus Phillips, an early settler of Phillips County and the namesake of Phillips County. As of the 2000 census, this portion of the city population was 6,323. Helena was the county seat of Phillips County until January 1, 2006, when it merged its government and city limits with neighboring West Helena.

Helena–West Helena is the county seat of and the largest city within Phillips County, Arkansas, United States. The current city was consolidated, effective January 1, 2006, from the two Arkansas cities of Helena and West Helena. Helena is sited on lowlands between the Mississippi River and the eastern side of Crowley's Ridge. West Helena is located on the western side of Crowley's Ridge, a geographic anomaly in the typically flat Arkansas Delta. The Helena Bridge, one of Arkansas' four Mississippi River bridges, carries U.S. Route 49 across to Mississippi. The combined population of the two cities was 15,012 at the 2000 census and at the 2010 census, the official population was 12,282.