Henry Frederick, Prince of Wales,, was the eldest son and heir apparent of James VI and I, King of England and Scotland; and his wife Anne of Denmark. His name derives from his grandfathers: Henry Stuart, Lord Darnley; and Frederick II of Denmark. Prince Henry was widely seen as a bright and promising heir to his father's thrones. However, at the age of 18, he predeceased his father, dying of typhoid fever. His younger brother Charles succeeded him as heir apparent to the English, Irish, and Scottish thrones.

James VI and I was King of Scotland as James VI from 24 July 1567 and King of England and Ireland as James I from the union of the Scottish and English crowns on 24 March 1603 until his death in 1625. Although he long tried to get both countries to adopt a closer political union, the kingdoms of Scotland and England remained sovereign states, with their own parliaments, judiciaries, and laws, ruled by James in personal union. He was the longest-reigning monarch of the Kingdom of Scotland.