Highbridge is a residential neighborhood geographically located in the central-west section of the Bronx, New York City. Its boundaries, starting from the north and moving clockwise, are the Cross-Bronx Expressway to the north, Jerome Avenue to the east, Macombs Dam Bridge to the south, and the Harlem River to the west. Ogden Avenue is the primary thoroughfare through Highbridge.

Jerome Avenue is one of the longest thoroughfares in the New York City borough of the Bronx, New York, United States. The road is 5.6 miles (9.0 km) long and stretches from Concourse to Woodlawn. Both of these termini are with the Major Deegan Expressway which runs parallel to the west. Most of the elevated IRT Jerome Avenue Line runs along Jerome Avenue. The Cross Bronx Expressway interchanges with Jerome and the Deegan. Though it runs through what is now the West Bronx neighborhood, Jerome Avenue is the dividing avenue between nominal and some named "West" and "East" streets in the Bronx; Fifth Avenue, and to a lesser extent, Broadway, also splits Manhattan into nominal "West" and "East" streets.