Jerome Avenue is one of the longest thoroughfares in the New York City borough of the Bronx, New York, United States. The road is 5.6 miles (9.0 km) long and stretches from Concourse to Woodlawn. Both of these termini are with the Major Deegan Expressway which runs parallel to the west. Most of the elevated IRT Jerome Avenue Line runs along Jerome Avenue. The Cross Bronx Expressway interchanges with Jerome and the Deegan. Though it runs through what is now the West Bronx neighborhood, Jerome Avenue is the dividing avenue between nominal and some named "West" and "East" streets in the Bronx; Fifth Avenue, and to a lesser extent, Broadway, also splits Manhattan into nominal "West" and "East" streets.

The Bronx is a borough of New York City, coextensive with Bronx County, in the U.S. state of New York. It is south of Westchester County; north and east of the New York City borough of Manhattan, across the Harlem River; and north of the New York City borough of Queens, across the East River. The Bronx is the only New York City borough not primarily located on an island. The Bronx has a land area of 42 square miles (109 km2) and a population of 1,472,654 in the 2020 census. If each borough were ranked as a city, the Bronx would rank as the ninth-most-populous in the U.S. Of the five boroughs, it has the fourth-largest area, fourth-highest population, and third-highest population density. The population density of the Bronx was 32,718.7 inhabitants per square mile (12,632.8/km2) in 2022, the third-highest population density of any county in the United States, behind Manhattan and Brooklyn. With a population that is 54.8% Hispanic as of 2020, it is the only majority-Hispanic county in the Northeastern United States and the fourth-most-populous nationwide.