Human spaceflight is spaceflight with a crew or passengers aboard a spacecraft, often with the spacecraft being operated directly by the onboard human crew. Spacecraft can also be remotely operated from ground stations on Earth, or autonomously, without any direct human involvement. People trained for spaceflight are called astronauts, cosmonauts (Russian), or taikonauts (Chinese); and non-professionals are referred to as spaceflight participants or spacefarers.

Spaceflight is an application of astronautics to fly objects, usually spacecraft, into or through outer space, either with or without humans on board. Most spaceflight is uncrewed and conducted mainly with spacecraft such as satellites in orbit around Earth, but also includes space probes for flights beyond Earth orbit. Such spaceflight operate either by telerobotic or autonomous control. The more complex human spaceflight has been pursued soon after the first orbital satellites and has reached the Moon and permanent human presence in space around Earth, particularly with the use of space stations. Human spaceflight programs include the Soyuz, Shenzhou, the past Apollo Moon landing and the Space Shuttle programs. Other current spaceflight are conducted to the International Space Station and to China's Tiangong Space Station.