The Imam Husayn Shrine is the mosque and burial site of Husayn ibn Ali, the third Imam of Shia Islam, in the city of Karbala, Iraq. It stands on the site of the Mausoleum of Husayn, who was a grandson of Muhammad, near the place where he embraced martyrdom during the Battle of Karbala in 680 CE The tomb of Husayn is one of the holiest sites in Shia Islam, outside of Mecca and Medina, and many make pilgrimages to the site. Every year, millions of pilgrims visit the city to observe Ashura, which marks the commemoration of Husayn's death for all Muslims.

Husayn ibn Ali was an Alid political and religious leader. The grandson of the Islamic prophet Muhammad and a son of Ali ibn Abi Talib and Muhammad's daughter Fatima, as well as a younger brother of Hasan ibn Ali, Husayn is regarded as the third Imam in Shia Islam after his brother, Hasan, and before his son, Ali al-Sajjad. Being the grandson of the prophet, he is the member of the ahl al-bayt. He is also considered to be a member of the Ahl al-Kisa, and a participant in the event of the mubahala. Muhammad described him and his brother, Hasan, as the leaders of the youth of Paradise.