The Indigenous peoples of the Great Basin are Native Americans of the northern Great Basin, Snake River Plain, and upper Colorado River basin. The "Great Basin" is a cultural classification of indigenous peoples of the Americas and a cultural region located between the Rocky Mountains and the Sierra Nevada, in what is now Nevada, and parts of Oregon, California, Idaho, Wyoming, and Utah. The Great Basin region at the time of European contact was ~400,000 sq mi (1,000,000 km2). There is very little precipitation in the Great Basin area which affects the lifestyles and cultures of the inhabitants.

The Great Basin is the largest area of contiguous endorheic watersheds, those with no outlets to the ocean, in North America. It spans nearly all of Nevada, much of Utah, and portions of California, Idaho, Oregon, Wyoming, and Baja California. It is noted for both its arid climate and the basin and range topography that varies from the North American low point at Badwater Basin in Death Valley to the highest point of the contiguous United States, less than 100 miles (160 km) away at the summit of Mount Whitney. The region spans several physiographic divisions, biomes, ecoregions, and deserts.