Interstate 264 (I-264) is a partial loop around the city of Louisville, Kentucky, south of the Ohio River. An auxiliary route of I-64, it is signed as the Shawnee Expressway for its first eight miles (13 km) from its western terminus at I-64/U.S. Route 150 (US 150) to US 31W/US 60 and as the Watterson Expressway for the remainder of its length from US 31W/US 60 to its northeastern terminus at I-71. It is 22.93 miles (36.90 km) in length and runs an open circle around central Louisville. It is the only auxiliary route of I-64 outside of Virginia.

Interstate 64 (I-64) in the US state of Kentucky travels for 191 miles (307 km), passing by the major towns and cities of Louisville, Frankfort, Lexington, and Ashland. It has several major junctions with other Interstates, including I-65, I-71, I-264, and I-265 in Louisville and I-75 in Lexington.