Interstate 275 (I-275), located in Florida, is a 60-mile-long (97 km) auxiliary Interstate Highway serving the Tampa Bay area. Its southern terminus is at I-75 near Palmetto, where I-275 heads west towards the Sunshine Skyway Bridge crossing over Tampa Bay. From that point, I-275 passes through St. Petersburg before crossing Tampa Bay again on the Howard Frankland Bridge, then continues through the city of Tampa, where it connects to an interchange with I-4 in Downtown Tampa. After the interchange, I-275 passes north through the Tampa suburbs to its northern terminus at I-75 in Wesley Chapel.

Interstate 75 (I-75) is a part of the Interstate Highway System that runs from the Hialeah–Miami Lakes border, a few miles northwest of Miami, to Sault Ste. Marie in the Upper Peninsula of Michigan. I-75 begins its national northward journey near Miami, running along the western parts of the Miami metropolitan area before traveling westward across Alligator Alley, resuming its northward direction in Naples, running along Florida's Gulf Coast, and passing the cities of Fort Myers, Punta Gorda, Venice, and Sarasota. The freeway passes through the Tampa Bay area before turning inward toward Ocala, Gainesville, and Lake City before leaving the state and entering Georgia. I-75 runs for 471 miles (758 km) in Florida, making it the longest Interstate in the state and also the longest in any state east of the Mississippi River. The Interstate's speed limit is 70 mph (110 km/h) for its entire length in Florida.