Interstate 481 (I-481) is an auxiliary Interstate Highway that serves as an eastern bypass of Syracuse, New York, in the US. It begins at its parent, I-81, in the city's southern end and travels through the eastern Syracuse suburbs of Jamesville, DeWitt, and Cicero before rejoining I-81 in the suburb of North Syracuse. Upon crossing I-81 in North Syracuse, I-481 continues northwest to Fulton and Oswego as New York State Route 481 (NY 481). I-481 is part of the Veterans Memorial Highway, which extends northward onto NY 481. Future plans call for I-481 to be decommissioned by a reroute of I-81 onto the freeway.

Interstate 81 (I-81) is a part of the Interstate Highway System that runs from I-40 at Dandridge, Tennessee, to the Thousand Islands Bridge at Wellesley Island in New York, beyond which the short 2.7-mile (4.3 km) Ontario Highway 137 (Highway 137) links it to Highway 401. In the US state of New York, I-81 extends 183.60 miles (295.48 km) from the Pennsylvania state line southeast of Binghamton to the Canadian border at Wellesley Island northwest of Alexandria Bay. The freeway runs north–south through Central New York, serving the cities of Binghamton, Syracuse, and Watertown. It passes through the Thousand Islands in its final miles and crosses two bridges, both part of the series of bridges known as the Thousand Islands Bridge.