Interstate 49 (I-49) is an Interstate Highway in the state of Arkansas. There are two main sections of the highway across different sides of the state. The southern section starts at the Louisiana state line, then runs to Texarkana, at the Texas state line. The northern section begins at I-40 and at U.S. Highway 71 (US 71) in Alma and runs north to the Missouri state line, where the freeway continues into Missouri. An additional small section south of Fort Smith is currently designated as Highway 549 until it is extended northward to the I-40 interchange, at which point it will become part of I-49.

Interstate 40 (I-40) is an east–west Interstate Highway that has a 284.69-mile (458.16 km) section in the U.S. state of Arkansas, connecting Oklahoma to Tennessee. The route enters Arkansas from the west just north of the Arkansas River near Dora. It travels eastward across the northern portion of the state, connecting the cities of Fort Smith, Clarksville, Russellville, Morrilton, Conway, North Little Rock, Forrest City, and West Memphis. I-40 continues into Tennessee, heading through Memphis. The highway has major junctions with I-540 at Van Buren, I-49 at Alma, I-30 in North Little Rock, and I-55 to Blytheville.