Interstate 55 (I-55) is a north–south Interstate Highway that has a 72.22-mile (116.23 km) section in the US state of Arkansas connecting sections in Tennessee and Missouri. The route enters Arkansas on the Memphis & Arkansas Bridge over the Mississippi River from Memphis, Tennessee. It travels northward through northeast Arkansas, connecting the cities of West Memphis and Blytheville. I-55 continues into Missouri heading to St. Louis, Missouri. The highway overlaps I-40 in West Memphis and has a junction with I-555, a spur route to Jonesboro, in Turrell. For the majority of its routing through Arkansas, I-55 generally follows U.S. Highway 61 (US 61) and has a 67.08-mile (107.95 km) long concurrency with US 78 from the Tennessee state line in Memphis to Blytheville for most of its length.

West Memphis is the largest city in Crittenden County, Arkansas, United States. The population was 26,245 at the 2010 census, ranking it as the state's 18th largest city, behind Bella Vista. It is part of the Memphis metropolitan area, and is located directly across the Mississippi River from Memphis, Tennessee.