Interstate 69E (I-69E) is a north–south Interstate Highway running through South Texas. Once complete, the freeway will begin in Brownsville and head northward before terminating near Victoria as both I-69W and I-69E merge into I-69 toward Houston. For its entire length, I-69E runs concurrently with U.S. Highway 77 (US 77). The route currently exists in two segments: a 56.894-mile (91.562 km) segment from its southern terminus in Brownsville to the Willacy–Kenedy county line and a shorter 7.672-mile (12.347 km) segment south of Corpus Christi. The route has one auxiliary Interstate route, I-169 in Brownsville.

The Dwight D. Eisenhower National System of Interstate and Defense Highways, commonly known as the Interstate Highway System, or the Eisenhower Interstate System, is a network of controlled-access highways that forms part of the National Highway System in the United States. The system extends throughout the contiguous United States and has routes in Hawaii, Alaska, and Puerto Rico.