Interstate 71 (I-71) is a north–south Interstate Highway in the midwestern and southeastern regions of the United States. Its southern terminus is at an interchange with I-64 and I-65 in Louisville, Kentucky, and its northern terminus at an interchange with I-90 in Cleveland, Ohio. I-71 runs concurrently with I-75 from a point about 20 miles (32 km) south of Cincinnati, Ohio, into Downtown Cincinnati. While most odd numbered Interstates run north–south, I-71 takes more of a northeast–southwest course, with some east–west sections, and is mainly a regional route serving Kentucky and Ohio. It links I-80 and I-90 to I-70 and ultimately links to I-40. Major metropolitan areas served by I-71 include Louisville, Cincinnati, Columbus, and Cleveland.

Interstate 64 (I-64) is an east–west Interstate Highway in the Eastern United States. Its western terminus is at I-70, U.S. Route 40 (US 40), and US 61 in Wentzville, Missouri. Its eastern terminus is at the Bowers Hill Interchange with I-264 and I-664 at Bower's Hill in Chesapeake, Virginia. I-64 connects Greater St. Louis, the Louisville metropolitan area, the Lexington–Fayette metropolitan area, the Charleston metropolitan area, the Greater Richmond Region, and Hampton Roads.