Interstate 74 (I-74) is a partially completed part of the Interstate Highway System that is planned to run from Davenport, Iowa, to Myrtle Beach, South Carolina. In the US state of North Carolina, I-74 currently exists in three distinct segments; from I-77 at the Virginia state line to US Highway 52 (US 52) near Mount Airy, from I-40 in Winston-Salem to US 220 near Ellerbe, and from US 74 and US 74 Business near Maxton to US 74/North Carolina Highway 41 (NC 41) near Lumberton. I-74 has an extensive concurrency with I-73 from Randleman to Ellerbe in the Piedmont. When completed, I-74 will link the cities of Mount Airy, Winston-Salem, High Point, Rockingham, Laurinburg, and Lumberton.

Interstate 77 (I-77) in the US state of Virginia is a 67-mile (108 km) north–south Interstate Highway serving Hillsville, Wytheville, and Bland. Running parallel to US Route 52 (US 52), I-77 passes through the Big Walker Mountain Tunnel and East River Mountain Tunnel, the latter on the West Virginia state line and one of only two land vehicular tunnels to cross a state line.