Interstate 80 (I-80) is a part of the Interstate Highway System that runs from San Francisco, California, to Teaneck, New Jersey. I-80 enters Illinois from Iowa in the west, southwest of Rapids City, and runs generally eastward through East Moline, LaSalle, and Joliet, before entering Indiana in Lansing. The Interstate runs for approximately 163.52 miles (263.16 km) through the state.

East Moline is a city in Rock Island County, Illinois, United States. The population was 21,374 at the 2020 census. East Moline is one of the Quad Cities at the confluence of the Rock and Mississippi rivers, along with neighboring Moline and Rock Island in Illinois and the cities of Davenport and Bettendorf in Iowa. As of 2011, the Quad Cities has a population estimate of 381,342.