Interstate 95 (I-95) is a major Interstate Highway, running along the East Coast of the United States from Florida to Maine. In South Carolina, I-95 runs approximately parallel to the Atlantic Ocean shore although about 50 miles (80 km) inland, from Hardeeville in the south to Dillon in the northeast. The route runs through the cities of Florence and Walterboro.

Hardeeville is a city in Jasper and Beaufort counties in the U.S. state of South Carolina. The population was 7,473 as of the 2020 census, an increase of over 150% since 2010. Hardeeville is included within the Hilton Head Island–Bluffton metropolitan area.