The Irish Rebellion of 1641 was an uprising by Catholics in Ireland, whose demands included an end to anti-Catholic discrimination, greater Irish self-governance, and return of confiscated Catholic lands. Its timing was partially driven by the dispute between Charles I and his opponents—the English Parliamentarians and Scottish Covenanters—which the rebels feared would lead to an invasion and further anti-Catholic measures. Beginning as an attempted coup d'état by Catholic gentry and military officers, it developed into a widespread rebellion and ethnic conflict with English and Scottish Protestant settlers. It led to the 1641–1653 Irish Confederate Wars, part of the Wars of the Three Kingdoms, with up to 20% of the Irish population becoming casualties.

Plantations in 16th- and 17th-century Ireland involved the confiscation of Irish-owned land by the English Crown and the colonisation of this land with settlers from Great Britain. The Crown saw the plantations as a means of controlling, anglicising and 'civilising' Gaelic Ireland. The main plantations took place from the 1550s to the 1620s, the biggest of which was the plantation of Ulster. The plantations led to the founding of many towns, massive demographic, cultural and economic changes, changes in land ownership and the landscape, and also to centuries of ethnic and sectarian conflict. They took place before and during the earliest English colonisation of the Americas, and a group known as the West Country Men were involved in both Irish and American colonization.