The Irish bouzouki is an adaptation of the Greek bouzouki. The newer Greek tetrachordo bouzouki was introduced into Irish traditional music in the mid-1960s by Johnny Moynihan of the folk group Sweeney's Men, who retuned it from its traditional Greek tuning C³F³A³D⁴ to G²D³A³D⁴, a tuning he had pioneered previously on the mandolin. Alec Finn, first in the Cana Band and subsequently in De Dannan, introduced the first Greek trichordo (3 course) bouzouki into Irish music.

The bouzouki is a musical instrument popular in Greece. It is a member of the long-necked lute family, with a round body with a flat top and a long neck with a fretted fingerboard. It has steel strings and is played with a plectrum producing a sharp metallic sound, reminiscent of a mandolin but pitched lower. It is the precursor to the Irish bouzouki, an instrument derived from the Greek bouzouki that is popular in Celtic, English, and North American folk music. There are two main types of Greek bouzouki: the trichordo (three-course) has three pairs of strings and the tetrachordo (four-course) has four pairs of strings. The instrument was brought to Greece in the early 1900s by Greek refugees from Anatolia, and quickly became the central instrument to the rebetiko genre and its music branches. It is now an important element of modern Laïko pop Greek music.