Isabel Sanford was an American stage, film, and television actress and comedian best known for her role as Louise "Weezy" Mills Jefferson on the CBS sitcoms All in the Family (1971–1975) and The Jeffersons (1975–1985). In 1981, she became the second African-American actress to win a Primetime Emmy Award after Gail Fisher and the first African-American actress to win for Outstanding Lead Actress in a Comedy Series.

Louise Jefferson is a character, portrayed by Emmy Award-winning actress Isabel Sanford, who appeared first in a supporting role on the television series All in the Family and was one of the main characters in its spinoff series, The Jeffersons. The role lasted from 1971 to 1985, from her debut on All in the Family through the final episode of The Jeffersons. She was often referred to as "Weezy" by her on-screen husband, George Jefferson, and sometimes as "Mrs. J." by her neighbor Archie Bunker and later by her neighbor Harry Bentley. She was first introduced on All in the Family as a neighbor of Archie and Edith Bunker. Sanford appeared in 252 out of the 253 episodes of The Jeffersons.