Issyk-Kul Region is one of the regions of Kyrgyzstan. Its capital is Karakol. It is surrounded by Almaty Region, Kazakhstan (north), Chüy Region (west), Naryn Region (southwest) and Xinjiang, China (southeast). It takes its name from Lake Issyk-Kul, the world's second-largest high altitude lake. Its total area is 43,735 km2 (16,886 sq mi). The resident population of the region was 501,933 as of January 2021. The region has a sizeable Russian minority.

Karakol, formerly Przhevalsk, is the fourth-largest city in Kyrgyzstan, near the eastern tip of Lake Issyk-Kul, about 150 kilometres (93 mi) from the Kyrgyzstan–China border and 380 kilometres (240 mi) from the capital Bishkek. It is the administrative capital of Issyk-Kul Region. Its area is 44 square kilometres (17 sq mi), and its resident population was 84,351 in 2021. To the north, on highway A363, is Tüp, and to the southwest Jeti-Ögüz resort.