Issyk-Kul Region is one of the regions of Kyrgyzstan. Its capital is Karakol. It is surrounded by Almaty Region, Kazakhstan (north), Chüy Region (west), Naryn Region (southwest) and Xinjiang, China (southeast). It takes its name from Lake Issyk-Kul, the world's second-largest high altitude lake. Its total area is 43,735 km2 (16,886 sq mi). The resident population of the region was 501,933 as of January 2021. The region has a sizeable Russian minority.

Chüy Region is the northernmost region (oblast) of the Kyrgyz Republic. This region surrounds the national capital of Kyrgyzstan, Bishkek. It is bounded on the north by Kazakhstan, and clockwise, Issyk-Kul Region, Naryn Region, Jalal-Abad Region, and Talas Region. Its administrative center is Bishkek. Its total area is 19,895 km2 (7,682 sq mi). The resident population of the region was 974,984 as of January 2021. The region has sizeable Russian and Dungan minorities. It takes its name from the river Chüy, that flows through the region.