Jaffa Road, also called Jaffa Street is one of the longest and oldest major streets in Jerusalem. It crosses the city from east to west, from the Old City walls to downtown Jerusalem, the western portal of Jerusalem and the Jerusalem-Tel Aviv highway. It is lined with shops, businesses, and restaurants. It joins with Ben Yehuda Street and King George Street to form the Downtown Triangle central business district. Major landmarks along Jaffa Road are Tzahal Square, Safra Square, Zion Square, Davidka Square, the triple intersection (Hameshulash) at King George V Street and Straus Street, the Ben Yehuda Street pedestrian mall, the Mahane Yehuda market, and the Jerusalem Central Bus Station. Jaffa Road has been redeveloped as a car-free pedestrian mall served by the Jerusalem Light Rail, as well as by the Jerusalem–Yitzhak Navon railway station directly adjacent to the Central Bus Station.

The Jerusalem Central Bus Station is the main bus depot in Jerusalem. Located on Jaffa Road near the entrance to the city, it serves Egged, Superbus and Dan intercity bus routes. City buses and light rail trains pick up and discharge passengers across the street on Jaffa Road and on Zalman Shazar Boulevard, which can be accessed via an underground pedestrian passageway. The entrance to Israel Railways' underground Navon Railway Station is located across the light rail stop in front of the station.