Jefferson Avenue is a 63.71-mile-long (102.53 km) scenic road along the eastern part of the Detroit metropolitan area in the southeastern part of the U.S. state of Michigan. It travels alongside Lake Erie, the Detroit River, and Lake St. Clair. This road also provides access to many recreational facilities in the area. West Jefferson Avenue is primarily commercial, while East Jefferson Avenue contains a historic residential district.

The East Jefferson Avenue Residential District in Detroit, Michigan, includes the Thematic Resource (TR) in the multiple property submission to the National Register of Historic Places which was approved on October 9, 1985. The structures are single-family and multiple-unit residential buildings with construction dates spanning nearly a century, from 1835 to 1931. The area is located on the lower east side of the city.