Jeffersonville is a city and the county seat of Clark County, Indiana, United States, situated along the Ohio River. Locally, the city is often referred to by the abbreviated name Jeff. It lies directly across the Ohio River to the north of Louisville, Kentucky, along I-65. The population was 49,447 at the 2020 census.

Clark County is a county in the U.S. state of Indiana, located directly across the Ohio River from Louisville, Kentucky. At the 2020 census, the population was 121,093. The county seat is Jeffersonville. Clark County is part of the Louisville/Jefferson County, KY–IN Metropolitan Statistical Area.