Jerzy Neyman was a Polish mathematician and statistician who spent the first part of his professional career at various institutions in Warsaw, Poland and then at University College London, and the second part at the University of California, Berkeley. Neyman first introduced the modern concept of a confidence interval into statistical hypothesis testing and co-revised Ronald Fisher's null hypothesis testing.

Sir Ronald Aylmer Fisher was a British polymath who was active as a mathematician, statistician, biologist, geneticist, and academic. For his work in statistics, he has been described as "a genius who almost single-handedly created the foundations for modern statistical science" and "the single most important figure in 20th century statistics". In genetics, his work used mathematics to combine Mendelian genetics and natural selection; this contributed to the revival of Darwinism in the early 20th-century revision of the theory of evolution known as the modern synthesis, being the one to most comprehensively combine the ideas of Gregor Mendel and Charles Darwin. For his contributions to biology, Richard Dawkins proclaimed Fisher as "the greatest of Darwin's successors". He is considered one of the founding fathers of Neo-Darwinism.