John Barrymore was an American actor on stage, screen, and radio. A member of the Drew and Barrymore theatrical families, he initially tried to avoid the stage, and briefly attempted a career as an artist, but appeared on stage together with his father Maurice in 1900, and then his sister Ethel the following year. He began his career in 1903 and first gained attention as a stage actor in light comedy, then high drama, culminating in productions of Justice (1916), Richard III (1920), and Hamlet (1922); his portrayal of Hamlet led to him being called the "greatest living American tragedian".

The Barrymore family, and the related Drew family, form a British-American acting dynasty which traces its acting roots to the mid-19th century London stage. After migrating to the United States, members of the family appeared in motion pictures.