John George II was a German prince of the House of Ascania and ruler of the principality of Anhalt-Dessau from 1660 to 1693.

Anhalt-Dessau was a principality of the Holy Roman Empire and later a duchy of the German Confederation. Ruled by the House of Ascania, it was created in 1396 following the partition of the Principality of Anhalt-Zerbst, and finally merged into the re-united Duchy of Anhalt in 1863. The capital of the state was Dessau in present-day Saxony-Anhalt.