The Kafue River is the longest river lying wholly within Zambia at about 1,576 kilometres (979 mi) long. Its water is used for irrigation and for hydroelectric power. It is the largest tributary of the Zambezi, and of Zambia's principal rivers, it is the most central and the most urban. More than 50% of Zambia's population live in the Kafue River Basin and of these around 65% are urban.

The Zambezi is the fourth-longest river in Africa, the longest east-flowing river in Africa and the largest flowing into the Indian Ocean from Africa. Its drainage basin covers 1,390,000 km2 (540,000 sq mi), slightly less than half of the Nile's. The 2,574 km (1,599 mi) river rises in Zambia and flows through eastern Angola, along the north-eastern border of Namibia and the northern border of Botswana, then along the border between Zambia and Zimbabwe to Mozambique, where it crosses the country to empty into the Indian Ocean.