The Kalamazoo Transportation Center is an intermodal complex in downtown Kalamazoo, Michigan. Amtrak and Greyhound provide regular service there. The center is also the major downtown transfer hub for Kalamazoo's Metro Transit bus system.

The Blue Water is a higher-speed passenger train service operated by Amtrak as part of its Michigan Services. The 319-mile (513 km) route runs from Chicago, Illinois, to Port Huron in Michigan's Blue Water Area, for which the train is named. Major stops are in Kalamazoo, Battle Creek, East Lansing, and Flint.