Karachay-Cherkessia, officially the Karachay-Cherkess Republic, is a republic of Russia located in the North Caucasus. It is administratively part of the North Caucasian Federal District. As of the 2021 census, Karachay-Cherkessia has a population of 469,865. Cherkessk is the largest city and the capital of the republic.

The republics are one type of federal subject of the Russian Federation. 21 republics are internationally recognized as part of Russia; another is under its de facto control. The original republics were created as nation states for ethnic minorities. The indigenous ethnicity that gives its name to the republic is called the titular nationality. However, due to centuries of Russian migration, a titular nationality may not be a majority of its republic's population.