Karim Khalili is an Afghan politician serving as leader of the Hezb-e Wahdat Islami Afghanistan party. Most recently he was Chief of the Afghan High Peace Council from 2017 until its dissolvement in 2019. He was selected as a candidate for Second Vice President of Afghanistan in 2002 by Hamid Karzai; they were elected in 2004 and left office in 2014. Since 1989, he has also been one of the main leaders of the Wahdat political party of Hazara.

Hezb-e Wahdat-e Islami Afghanistan, shortened to Hezbe Wahdat, is an Afghan political party founded in 1989. Like most contemporary major political parties in Afghanistan, Hezb-e Wahdat is rooted in the turbulent period of the anti-Soviet resistance movements in Afghanistan in the 1980s. It was formed to bring together nine separate and mostly inimical military and ideological groups into a single entity.