Karlsruhe is the third-largest city of the German state of Baden-Württemberg, after its capital Stuttgart and Mannheim, and the 22nd-largest city in the nation, with 308,436 inhabitants. It is also a former capital of Baden, a historic region named after Hohenbaden Castle in the city of Baden-Baden. Located on the right bank of the Rhine near the French border, between the Mannheim-Ludwigshafen conurbation to the north and Strasbourg to the south, Karlsruhe is Germany's legal center, being home to the Federal Constitutional Court, the Federal Court of Justice and the Public Prosecutor General.

Baden-Württemberg, commonly shortened to BW or BaWü, is a German state in Southwest Germany, east of the Rhine, which forms the southern part of Germany's western border with France. With more than 11.07 million inhabitants as of 2019 across a total area of nearly 35,752 km2 (13,804 sq mi), it is the third-largest German state by both area and population. As a federated state, Baden-Württemberg is a partly-sovereign parliamentary republic. The largest city in Baden-Württemberg is the state capital of Stuttgart, followed by Mannheim and Karlsruhe. Other major cities are Freiburg im Breisgau, Heidelberg, Heilbronn, Pforzheim, Reutlingen, Tübingen, and Ulm.