The Kaskaskia were one of the indigenous peoples of the Northeastern Woodlands. They were one of about a dozen cognate tribes that made up the Illiniwek Confederation, also called the Illinois Confederation. Their longstanding homeland was in the Great Lakes region. Their first contact with Europeans reportedly occurred near present-day Green Bay, Wisconsin, in 1667 at a Jesuit mission station.

Indigenous peoples of the Northeastern Woodlands include Native American tribes and First Nation bands residing in or originating from a cultural area encompassing the northeastern and Midwest United States and southeastern Canada. It is part of a broader grouping known as the Eastern Woodlands. The Northeastern Woodlands is divided into three major areas: the Coastal, Saint Lawrence Lowlands, and Great Lakes-Riverine zones.