Kathryn Joosten was an American actress. Her best known roles include Dolores Landingham on NBC's The West Wing from 1999 to 2002 and Karen McCluskey on ABC's Desperate Housewives from 2005 to 2012, for which she won two Primetime Emmy Awards in 2005 and 2008.

Karen McCluskey is a fictional character from the ABC television series Desperate Housewives. The role was played by Kathryn Joosten, who won the Primetime Emmy Award twice for Outstanding Guest Actress in a Comedy Series in 2005 and 2008. In the series finale, Karen succumbs to cancer. This was agreed upon between Marc Cherry and Kathryn since she was battling cancer in real life as well. Kathryn Joosten died 20 days after the series finale aired.